Coxme and the Laplace Approximation
نویسنده
چکیده
where λ0 is an unspecified baseline hazard function, X and Z are the design matrices for the fixed and random effects, respectively, β is the vector of fixed-effects coefficients and b is the vector of random effects coefficients. The random effects distribution G is modeled as Gaussian with mean zero and a variance matrix Σ, which in turn depends a vector of parameters θ. The MLE for the variance of the random effects is based on an integrated partial likelihood
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تاریخ انتشار 2011